To make sure that you won't lose your account, make a Konami ID account and bind your game data/account to the Konami ID. This will make sure that even if you uninstall the app, you can recover your account, as well as being able to transfer your account to different devices. → How to transfer/save game data
1. Pick a starter duelist
Yami Yugi or Kaiba Seto?
In the beginning of the game, you will be asked to choose a starter from the two: Yami Yugi or Seto Kaiba. Yami Yugi focuses on Fiends and Spellcaster type monsters, while Seto Kaiba focuses more on Dragons and Winged Beast type monsters. It is fine to choose whichever one you prefer since you will be able to unlock the other character later in the game at stage 15.
2. Learn Speed Duel
Duel Links uses speed duel format. Check the differences between speed duel rules compared to the OCG/TCG!
If you are new to Yu-Gi-Oh, just play the game to learn the basics. The game also helps you by giving a tutorial at the start of the game, and through the Duel School/Quiz.
In the game, players can open a pack by spending Gems, that they can obtain by making an in-app purchase, farming, or giveaways. Gems are not used for anything else, other than to buy packs. They are somewhat limited if you don't purchase them, which is why it's better to carefully plan on what you want to get, and use them wisely on certain boxes instead of buying everything.
4. Plan what deck you want to build
You should find a deck you want to play and pick an appropriate booster pack that contains cards what you need. Consumes Gem efficiently to avoid in-app purchase.
A full respawn of standard duelists happen when you proceed to the next stage. Defeating all of them before proceeding will prevent any wasted exp for leveling your character, and saves you from using Duel Orbs. →Details of Duel Orb.
Complete all missions for the current stage.
Duel against all the available Standard Duelists before going to the next stage.
Note: Once you receive the reward for "Complete all Stage Missions [#]", you are moved up to the next stage.
Receive the reward for "Complete all Stage Missions [#]" when you are out of Standard Duelists to proceed to the next stage.
All of the Standard Duelists will fully respawn.
7. Use LIGHT monster and Trap cards actively
Summon LIGHT-attribute monster and activate Trap cards frequently from the early stage of the game. That is the key to unlock Ishizu and Odion smoothly.
To duel against Legendary Duelists at the Gate, you need need to have colored keys, and a certain amount of them, depending on what level you want to duel them. Here are some tips for using Gate Keys wisely. → Details of Gate Key
Beat them to complete Stage missions
Some stage missions require you to defeat Legendary Duelists, so be sure to save/keep some keys for those missions.
Pick cards you want to obtain
Aside from Kaiba, most Legendary Duelists uses a certain colored keys, which are shared with 1 other LD. Look at their victory rewards and determine which one you want to farm first so you can better manage your keys.
Card Trader is unlocked when you reach Stage 7. He offers cards that you cannot obtain by purchasing boosters, leveling up characters, and winning duels. You need to have trader items to get card from him. → Trader item: Gold → Trader item: Stone and Jewel
11. Trade a card to complete Stage mission
It is the best to trade a card while card trading Stage/Weekly missions appear.
Card Trading missions
Make a trade with the Card Trader 1 time(s).
Make a trade with the Card Trader 1 time(s).
Make a trade with the Card Trader 3 time(s).
12. Cerberus for farming decks
Mythical Beast Cerberus is a very useful card that is good for farming Legendary Duelists, and it's also new player friendly. While it is expensive to get at first, you only need to get 1 copy of this card. → High Score Cerberus: deck recipe
You must not convert Legendary Duelists' signature cards that you obtain in their starter decks into trader item, since some of Stage 48 missions asks you to use those cards 3 times each. Most cards that you obtain from levelling characters are also exclusive, not obtainable elsewhere, so be sure to not convert them.
When you visit Card Trader, you can convert a card into trader items, such as Gold and Stone/Jewel.
Part of Stage 48 missions
Normal Summon Dark Magician Girl 3 times.
Normal Summon The Legendary Fisherman 3 times.
Normal Summon Barrel Dragon 3 times.
Normal Summon Blue-Eyes White Dragon 3 times.
Normal Summon Dark Magician 3 times.
Use Blast Held by a Tribute 3 times.
I've already sold a signature card. What should I do?
Fortunately you can get those signature cards as reward for winning duels against legendary duelists who use them. See character details pages or Duel Reward Tier List.
Otherwise, you can use the card Exchange when dueling against the LD to take it from them so you can use it.
Check this page for an advanced guide to improve your game.
Choosing Kaiba gives you better chance for a 3000 or more damage for another 500 points. By the time you unlock the lvl 30 Kaiba deck to farm Enemy Controller, you already have unlocked a few characters already and Yugi as well.
u can still change your character and duel kaiba. so technically, it doesnt matter who u pick. Just a bit more efficient if u pick yugi bcuz at stage 15/16, the stage mission require u to battle kaiba lvl 30. just that advantage, nothing else i believe