Most Worm monsters work best when they are set. Most have good flip effects, while some you will just need to play face down for different reasons. One weakness of playing Worms is their lack of attack power, which we will compensate with the skill The Tie that Binds and the field spell Luminous Spark.
Most Worm monsters can support and are supported by other Worm monsters:
Worm Cartaros can search out any level 4 or lower Worm monster when he is flipped face-up.
Worm Solid gains defense points for every Worm monster in your graveyard. This can do considerable damage to your opponent when he unknowingly attacks your face-down Worm Solid, also allowing you to destroy their spell/trap card.
Worm Tentacles can remove a Worm monster in your graveyard from play so that he can attack twice for this turn's battle phase.
Since the current Worm monsters mostly have low to below average attack, you may not benefit much from effects like Worm Tentacles's "double attack" and Gamushara. So having attack boosts like Luminous Spark is essential to this deck. The skill The Tie that Binds can also help by giving you a temporary attack boost during your turn only.
Gamushara is used to punish your opponent for attacking your set monster. The best way to use this is when you set Worm Dimikles, then when your opponent attacks it use Gamushara. Worm Dimikles gains 300 attack and defense while your opponent receives double damage if their monster was destroyed, plus you can do more damage if Luminous Spark is face-up.