We can try, but the result may be unsatisfactory. To get Slifer to work, you need to: 1. Summon it, which is a challenge in itself. 2. Protect it from being destroyed or in case it gets stolen by E-con. 3. Allow it to actually gain ATK. 4. Clear your opponent's backrow so that you can get a hit in. As you can see, hitting all 4 is kind of a challenge... which one do you want to work on first?
For example, look at Exo's deck below. It'll successfully accomplish point 1 and 3: summoning and powering Slifer. However, it will encounter trouble if his opponent just destroys Slifer. The guy who uses Ojama should fare better, since it has a way to OTK and clearing the backrow... Although it will face a different problem of being inconsistent. Not belittling them, but it isn't easy.
BubblePig
Aquablast
